Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1
Identifieur interne : 001209 ( Main/Exploration ); précédent : 001208; suivant : 001210Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1
Auteurs : M. Emdadul Haque ; Matthew P. Mount ; Farzaneh Safarpour ; Elizabeth Abdel-Messih ; Steve Callaghan ; Chantal Mazerolle ; Tohru Kitada ; Ruth S. Slack ; Valerie Wallace ; Jie Shen ; Hymie Anisman ; David S. ParkSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Adenoviridae (genetics), Animals, Dopaminergic Neurons (drug effects), Dopaminergic Neurons (physiology), Gene Transfer Techniques, Genes, Recessive, Intracellular Signaling Peptides and Proteins (genetics), Intracellular Signaling Peptides and Proteins (metabolism), MPTP Poisoning (genetics), MPTP Poisoning (metabolism), Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Degeneration (chemically induced), Nerve Degeneration (genetics), Nerve Degeneration (metabolism), Neurotoxins (pharmacology), Oncogene Proteins (genetics), Oncogene Proteins (metabolism), Protein Deglycase DJ-1, Protein Kinases (genetics), Protein Kinases (metabolism), RNA, Small Interfering (genetics), Stress, Physiological (physiology), Ubiquitin-Protein Ligases (genetics), Ubiquitin-Protein Ligases (metabolism).
- MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases, RNA, Small Interfering, Ubiquitin-Protein Ligases.
- chemical , metabolism : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases, Ubiquitin-Protein Ligases.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neurotoxins.
- chemically induced : Nerve Degeneration.
- drug effects : Dopaminergic Neurons.
- genetics : Adenoviridae, MPTP Poisoning, Nerve Degeneration.
- metabolism : MPTP Poisoning, Nerve Degeneration.
- physiology : Dopaminergic Neurons, Stress, Physiological.
- Animals, Gene Transfer Techniques, Genes, Recessive, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Protein Deglycase DJ-1.
Abstract
Url:
DOI: 10.1074/jbc.M112.346437
PubMed: 22511790
PubMed Central: 3391096
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inactivation of <italic>Pink1</italic> Gene <italic>in Vivo</italic> Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, <italic>Parkin</italic> or <italic>DJ-1</italic></title><author><name sortKey="Haque, M Emdadul" sort="Haque, M Emdadul" uniqKey="Haque M" first="M. Emdadul" last="Haque">M. Emdadul Haque</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mount, Matthew P" sort="Mount, Matthew P" uniqKey="Mount M" first="Matthew P." last="Mount">Matthew P. Mount</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Safarpour, Farzaneh" sort="Safarpour, Farzaneh" uniqKey="Safarpour F" first="Farzaneh" last="Safarpour">Farzaneh Safarpour</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Abdel Messih, Elizabeth" sort="Abdel Messih, Elizabeth" uniqKey="Abdel Messih E" first="Elizabeth" last="Abdel-Messih">Elizabeth Abdel-Messih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mazerolle, Chantal" sort="Mazerolle, Chantal" uniqKey="Mazerolle C" first="Chantal" last="Mazerolle">Chantal Mazerolle</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kitada, Tohru" sort="Kitada, Tohru" uniqKey="Kitada T" first="Tohru" last="Kitada">Tohru Kitada</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S." last="Slack">Ruth S. Slack</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wallace, Valerie" sort="Wallace, Valerie" uniqKey="Wallace V" first="Valerie" last="Wallace">Valerie Wallace</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Anisman, Hymie" sort="Anisman, Hymie" uniqKey="Anisman H" first="Hymie" last="Anisman">Hymie Anisman</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22511790</idno><idno type="pmc">3391096</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391096</idno><idno type="RBID">PMC:3391096</idno><idno type="doi">10.1074/jbc.M112.346437</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000565</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000565</idno><idno type="wicri:Area/Pmc/Curation">000565</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000565</idno><idno type="wicri:Area/Pmc/Checkpoint">000813</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000813</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000A53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A53</idno><idno type="wicri:Area/PubMed/Curation">000A53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A53</idno><idno type="wicri:Area/PubMed/Checkpoint">000A53</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A53</idno><idno type="wicri:Area/Ncbi/Merge">001126</idno><idno type="wicri:Area/Ncbi/Curation">001126</idno><idno type="wicri:Area/Ncbi/Checkpoint">001126</idno><idno type="wicri:Area/Main/Merge">001234</idno><idno type="wicri:Area/Main/Curation">001209</idno><idno type="wicri:Area/Main/Exploration">001209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Inactivation of <italic>Pink1</italic> Gene <italic>in Vivo</italic> Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, <italic>Parkin</italic> or <italic>DJ-1</italic></title><author><name sortKey="Haque, M Emdadul" sort="Haque, M Emdadul" uniqKey="Haque M" first="M. Emdadul" last="Haque">M. Emdadul Haque</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mount, Matthew P" sort="Mount, Matthew P" uniqKey="Mount M" first="Matthew P." last="Mount">Matthew P. Mount</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Safarpour, Farzaneh" sort="Safarpour, Farzaneh" uniqKey="Safarpour F" first="Farzaneh" last="Safarpour">Farzaneh Safarpour</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Abdel Messih, Elizabeth" sort="Abdel Messih, Elizabeth" uniqKey="Abdel Messih E" first="Elizabeth" last="Abdel-Messih">Elizabeth Abdel-Messih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mazerolle, Chantal" sort="Mazerolle, Chantal" uniqKey="Mazerolle C" first="Chantal" last="Mazerolle">Chantal Mazerolle</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kitada, Tohru" sort="Kitada, Tohru" uniqKey="Kitada T" first="Tohru" last="Kitada">Tohru Kitada</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S." last="Slack">Ruth S. Slack</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wallace, Valerie" sort="Wallace, Valerie" uniqKey="Wallace V" first="Valerie" last="Wallace">Valerie Wallace</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Anisman, Hymie" sort="Anisman, Hymie" uniqKey="Anisman H" first="Hymie" last="Anisman">Hymie Anisman</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term><term>Adenoviridae (genetics)</term><term>Animals</term><term>Dopaminergic Neurons (drug effects)</term><term>Dopaminergic Neurons (physiology)</term><term>Gene Transfer Techniques</term><term>Genes, Recessive</term><term>Intracellular Signaling Peptides and Proteins (genetics)</term><term>Intracellular Signaling Peptides and Proteins (metabolism)</term><term>MPTP Poisoning (genetics)</term><term>MPTP Poisoning (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Nerve Degeneration (chemically induced)</term><term>Nerve Degeneration (genetics)</term><term>Nerve Degeneration (metabolism)</term><term>Neurotoxins (pharmacology)</term><term>Oncogene Proteins (genetics)</term><term>Oncogene Proteins (metabolism)</term><term>Protein Deglycase DJ-1</term><term>Protein Kinases (genetics)</term><term>Protein Kinases (metabolism)</term><term>RNA, Small Interfering (genetics)</term><term>Stress, Physiological (physiology)</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>Ubiquitin-Protein Ligases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Oncogene Proteins</term><term>Protein Kinases</term><term>RNA, Small Interfering</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Oncogene Proteins</term><term>Protein Kinases</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Neurotoxins</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dopaminergic Neurons</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term><term>MPTP Poisoning</term><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>MPTP Poisoning</term><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dopaminergic Neurons</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Transfer Techniques</term><term>Genes, Recessive</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Protein Deglycase DJ-1</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Mutations in <italic>Pink1</italic> are associated with Parkinson disease.</p><p><bold>Results:</bold> Mouse <italic>Pink1</italic> deficiency results in hypersensitivity to MPTP-induced dopaminergic neuronal loss, which can be rescued with expression of human <italic>Parkin</italic> or <italic>DJ-1</italic>.</p><p><bold>Conclusion:</bold><italic>Pink1</italic> gene can regulate response to exogenous stress.</p><p><bold>Significance:</bold> These results indicate how endogenous <italic>Pink1</italic> plays an important role in management of exogenous stress in mouse brain.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Abdel Messih, Elizabeth" sort="Abdel Messih, Elizabeth" uniqKey="Abdel Messih E" first="Elizabeth" last="Abdel-Messih">Elizabeth Abdel-Messih</name><name sortKey="Anisman, Hymie" sort="Anisman, Hymie" uniqKey="Anisman H" first="Hymie" last="Anisman">Hymie Anisman</name><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><name sortKey="Haque, M Emdadul" sort="Haque, M Emdadul" uniqKey="Haque M" first="M. Emdadul" last="Haque">M. Emdadul Haque</name><name sortKey="Kitada, Tohru" sort="Kitada, Tohru" uniqKey="Kitada T" first="Tohru" last="Kitada">Tohru Kitada</name><name sortKey="Mazerolle, Chantal" sort="Mazerolle, Chantal" uniqKey="Mazerolle C" first="Chantal" last="Mazerolle">Chantal Mazerolle</name><name sortKey="Mount, Matthew P" sort="Mount, Matthew P" uniqKey="Mount M" first="Matthew P." last="Mount">Matthew P. Mount</name><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><name sortKey="Safarpour, Farzaneh" sort="Safarpour, Farzaneh" uniqKey="Safarpour F" first="Farzaneh" last="Safarpour">Farzaneh Safarpour</name><name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S." last="Slack">Ruth S. Slack</name><name sortKey="Wallace, Valerie" sort="Wallace, Valerie" uniqKey="Wallace V" first="Valerie" last="Wallace">Valerie Wallace</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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